[Membre-smv] Interference Fièvre jaune et ROR

[julian cornaglia]

Bonjour a tous,
Je savais qu'il avait un étude français "Vaccin FJ et ROR" en cours (ou déjà fini ?)...
Un article va aparaître en "Vaccine" (Article en Press).
Des commentaires ?
Dr Julian CORNAGLIA
SMIT-CH Perpignan
 
Mutual interference on the immune response to yellow fever vaccine and a combined vaccine against measles, mumps and rubella 





 
Juliana Romualdo Nascimento Silvaa, , Luiz Antonio B. Camachoa, , , , Marilda M. Siqueirab, , Marcos da Silva Freirec, , Yvone P. Castrod, , Maria de Lourdes S. Maiae, , Anna Maya Y. Yamamuraf, , Reinaldo M. Martinsg, , Maria da Luz F. Lealh,  and Collaborative Group for the Study of Yellow Fever Vaccines1



a Departamento de Epidemiologia, Escola Nacional de Saúde Pública, FIOCRUZ, Rua Leopoldo Bulhões, 1480, sala 820, Manguinhos, Rio de Janeiro 21041-210, RJ, Brazil
b Laboratório de Vírus Respiratórios e do Sarampo (LVRS), Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Helio e Peggy Pereira, sala B105, Rua Leopoldo Bulhões 1480, Manguinhos, Rio de Janeiro 21041-210, RJ, Brazil
c Vice-Diretoria de Desenvolvimento Tecnológico de Bio-Manguinhos, FIOCRUZ, Av. Brasil, 4365 – Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil
d Programa de Imunizações da Secretaria Distrital de Saúde, SGAP, Lote 6, Bloco G, Parque de Apoio, SIA, Brasilia 71-410-010, DF, Brazil
e Assessoria Clínica, Bio-Manguinhos, FIOCRUZ, Av. Brasil, 4365 – Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil
f Laboratorio de Tecnologia Virológica, Bio-Manguinhos, FIOCRUZ, Av. Brasil, 4365 – Pavilhão Rocha Lima, Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil
g Consultor Científico, Bio-Manguinhos, FIOCRUZ, Av. Brasil, 4365 – Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil
h Vice-Diretoria de Qualidade de Bio-Manguinhos, FIOCRUZ, Av. Brasil, 4365 – Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil
Received 21 November 2010;  
revised 5 May 2011;  
accepted 9 May 2011.  
Available online 2 June 2011. 








Abstract
A randomized trial was conducted to assess the immunogenicity and reactogenicity of yellow fever vaccines (YFV) given either simultaneously in separate injections, or 30 days or more after a combined measles–rubella–mumps (MRM) vaccine. Volunteers were also randomized to YFV produced from 17DD and WHO-17D-213 substrains. The study group comprised 1769 healthy 12-month-old children brought to health care centers in Brasilia for routine vaccination. The reactogenicity was of the type and frequency expected for the vaccines and no severe adverse event was associated to either vaccine. Seroconversion and seropositivity 30 days or more after vaccination against yellow fever was similar across groups defined by YFV substrain. Subjects injected YFV and MMR simultaneously had lower seroconversion rates – 90% for rubella, 70% for yellow fever and 61% for mumps – compared with those vaccinated 30 days apart – 97% for rubella, 87% for yellow fever and 71% for mumps. Seroconversion rates for measles were higher than 98% in both comparison groups. Geometric mean titers for rubella and for yellow fever were approximately three times higher among those who got the vaccines 30 days apart. For measles and mumps antibodies GMTs were similar across groups. MMR's interference in immune response of YFV and YFV's interference in immune response of rubella and mumps components of MMR had never been reported before but are consistent with previous observations from other live vaccines. These results may affect the recommendations regarding primary vaccination with yellow fever vaccine and MMR.
  		 	   		  
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